DynaMed Weekly Update

September 22, 2009

Volume 4 Issue 38

DynaMed Systematic Literature Surveillance

For the week ending September 18, 2009

Last week 588 articles were evaluated via DynaMed’s Systematic Literature Surveillance and 201 were added to DynaMed content.

Based on the editors’ criteria of selecting “articles most likely to change clinical practice,” one article of significant interest was selected for the DynaMed Weekly Update.

Implantable Cardioverter-Defibrillators Do Not Appear to Reduce Mortality in Women with Heart Failure

Implantable cardioverter-defibrillators (ICDs) are frequently advised for patients with heart failure who are at increased risk for sudden cardiac death. However, a new systematic review suggests that ICDs may not provide any survival benefit to women with heart failure and left ventricular dysfunction (level 2 [mid-level] evidence). In a subgroup analysis of 934 women from 5 randomized trials with 20-46 months follow-up, there was no significant difference in all-cause mortality comparing ICDs vs. medical therapy (hazard ratio 1.01). ICDs were associated with lower all-cause mortality in men (hazard ratio 0.78, 95% CI 0.7-0.87) (Arch Intern Med 2009 Sep 14;169(16):1500). Additionally, in a recent cohort of 161,470 patients, periprocedural major adverse event rates were higher for women than for men (2% vs. 1.1%, p < 0.001) (Circulation 2009 Mar 3;119(8):1078).

For more information, see the Implantable cardioverter-defibrillator (ICD) topic in DynaMed.

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DynaMed Topic Activity

New summaries added to DynaMed this week:

· Androgen deprivation therapy for prostate cancer

· Plasma Protein Fraction

· Urokinase

DynaMed Peer Review

We are currently seeking reviewers for:

· Colon carcinoma

· Doripenem

· Miglitol

For more information, see Editorial Policies for Authors & Reviewers and DynaMed Peer Review.

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DynaMed Weekly Update Archives

DynaMed Weekly Update is a compilation of 1 to 5 articles that are of significant interest to clinicians. Articles are selected from DynaMed's Systematic Literature Surveillance as articles most likely to change clinical practice. Updates are prepared by the DynaMed Editorial Team which includes 28 clinicians from multiple disciplines. Send comments to DynaMedEditor@epnet.com. To learn more about DynaMed, go to www.dynamicmedical.com.

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Copyright © 2009 EBSCO Publishing. All rights reserved.
DynaMed® is a registered trademark of and published by DynaMed LLC. Original date of on-line publication December 15, 1995 with continuous daily updating. ISSN: 1554-1177. Subscriptions and queries can be addressed to DynaMed LLC, EBSCO Publishing, 10 Estes St., Ipswich, Massachusetts, USA 01938-0602, telephone (978) 356-6500, facsimile (978) 356-6565, e-mail Editor@DynamicMedical.com. The opinions expressed herein are solely those of the authors and editors and may or may not represent the official position of cooperating or endorsing Medical Societies. Development of DynaMed was supported in part by the National Science Foundation through a Small Business Innovative Research grant. (All other support comes from subscriptions. No advertisements are accepted.)