DynaMed Weekly Update

October 6, 2009

Volume 4 Issue 40

DynaMed Systematic Literature Surveillance

For the week ending October 2, 2009

Last week 725 articles were evaluated via DynaMed’s Systematic Literature Surveillance and 242 were added to DynaMed content.

Based on the editors’ criteria of selecting “articles most likely to change clinical practice,” one article of significant interest was selected for the DynaMed Weekly Update.

Intramuscular Trivalent Inactivated Vaccine may be More Effective than Intranasal Live Attenuated Vaccine for Seasonal Flu in Healthy Adults

Intramuscular and intranasal seasonal influenza vaccines were compared to each other and to placebo in a randomized trial with 1,952 healthy adults followed during the 2007-2008 influenza season (N Engl J Med 2009 Sep 24;361(13):1260). The rate of laboratory-confirmed symptomatic influenza was 6.1% overall, with lowest incidence (3.4%) occurring in the group receiving intramuscular inactivated trivalent vaccine (Fluzone) (level 2 [mid-level] evidence). The rate of laboratory-confirmed symptomatic influenza was significantly higher for both live attenuated influenza vaccine (FluMist) (6.9%) and placebo (10.8%). The Number Needed to Treat (NNT) to prevent 1 case of symptomatic seasonal influenza using the inactivated vaccine was 29 compared with live attenuated vaccine and 14 compared with placebo. Arm soreness was the only significant adverse effect associated with the inactivated vaccine. The live attenuated vaccine appeared superior to placebo, with a NNT of 26.

For more information, see the Influenza Virus Vaccine Live Intranasal topic in DynaMed.

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DynaMed Topic Activity

New summaries added to DynaMed this week:

· Differentiating beta-thalassemia trait from iron deficiency anemia

· Milk protein allergy

DynaMed Peer Review

We are currently seeking reviewers for:

· Disseminated intravascular coagulation (DIC)

· Hepatitis A Virus Vaccine Inactivated

· Hyponatremia (hypotonic)

For more information, see Editorial Policies for Authors & Reviewers and DynaMed Peer Review.

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DynaMed Weekly Update Archives

DynaMed Weekly Update is a compilation of 1 to 5 articles that are of significant interest to clinicians. Articles are selected from DynaMed's Systematic Literature Surveillance as articles most likely to change clinical practice. Updates are prepared by the DynaMed Editorial Team which includes 28 clinicians from multiple disciplines. Send comments to DynaMedEditor@epnet.com. To learn more about DynaMed, go to www.dynamicmedical.com.

Published by DynaMed
Copyright © 2009 EBSCO Publishing. All rights reserved.
DynaMed® is a registered trademark of and published by DynaMed LLC. Original date of on-line publication December 15, 1995 with continuous daily updating. ISSN: 1554-1177. Subscriptions and queries can be addressed to DynaMed LLC, EBSCO Publishing, 10 Estes St., Ipswich, Massachusetts, USA 01938-0602, telephone (978) 356-6500, facsimile (978) 356-6565, e-mail Editor@DynamicMedical.com. The opinions expressed herein are solely those of the authors and editors and may or may not represent the official position of cooperating or endorsing Medical Societies. Development of DynaMed was supported in part by the National Science Foundation through a Small Business Innovative Research grant. (All other support comes from subscriptions. No advertisements are accepted.)